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Stem Cell Therapy for Diabetic Kidney Disease: A Phase 2 Trial Worth Watching; But Not Yet Acting On
Andrew Kowalski, MD, FASN A summary and commentary on: Čižman B, Butler EL, Stavas J, et al. A Randomized Clinical Trial of Kidney Autologous Cell Therapy in Diabetic Kidney Disease. Clin J Am Soc Nephrol. Published January 2, 2026. doi:10.2215/CJN.0000000969 So if you have not heard, there has been some excitement in the world of kidney disease lately! A article came out in 1/2026 discussing a possible, and promising, use of stem cell therapy to address diabetic kidney disea
Andrew Kowalski
6 days ago5 min read


Chronic Kidney Disease and SGLT2 Inhibitors: From Glucose Drugs to Renal Protection Pillars
An updated version from the last post Andrew Kowalski, MD, FASN CKD remains one of the most underdiagnosed and undertreated conditions in modern medicine, affecting more than one in ten adults worldwide and dramatically increasing the risk of cardiovascular disease, kidney failure, and premature death . For decades, our therapeutic approach rested on a familiar foundation, The Big 4: Blood pressure control Renin-angiotensin system blockade Glycemic management in those with d
Andrew Kowalski
Mar 37 min read


Physical Activity and Kidney Function Preservation: Insights from Measured GFR Trajectories
Andrew Kowalski, MD FASN I have been an advocate for exercise among CKD patients for a long time. Fortunately, there have been numerous publications showing significant benefit among CKD patients. From numerous cardiovascular benefits to evidence that it can help lower chronic inflammation and delay CKD progression. I was excited to see another study looking at physical activity and preserving kidney function. The RENIS study from Tromsø, Northern Norway , asked a clinically
Andrew Kowalski
Feb 183 min read


We Can Actually do Something and Finally Move to a Proactive Culture in Nephrology
Andrew Kowalski, MD, FASN Nephrology has historically centered on the management of advanced CKD, dialysis, and transplantation. It does dabble in other issues, but I would consider these 3 to be the foundation of our speciality. CKD affects nearly 10% of the global population and is a leading contributor to morbidity, mortality, and health care costs. Guess what? The numbers are going up and the number of doctors are dropping! So, what do we do now??? Traditionally, calling
Andrew Kowalski
Jan 195 min read


Chronic Kidney Disease in 2025: From Silent Epidemic to Treatable Risk State
Andrew Kowalski, MD, FASN Understanding Chronic Kidney Disease: A Growing Concern Chronic Kidney Disease (CKD) has emerged as a significant challenge in global health. Current estimates indicate that approximately 850 million people worldwide live with CKD, with around 4 million receiving dialysis or living with a kidney transplant (Herrington et al., 2025). These numbers are staggering. What makes them alarming is the trajectory: CKD is projected to become the fifth leading
Andrew Kowalski
Nov 30, 20257 min read
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